清华化工论坛第四十八讲

报告题目：Microreactors: From automated optimization to flexible on-demand manufacturing

报告人👨‍👨‍👧⛹️‍♀️：Klavs F. Jensen Warren K. Lewis Professor, Department of Chemical Engineering, Massachusetts Institute of Technology

报告时间：11月13日（周一）10:00 - 11:30

报告地点🏊🏿：英士楼 201会议室

个人简介⬛️：

Professor Jensen received his Ph.D. in chemical engineering from the University of Wisconsin-Madison. His research interests revolve around microfabrication, testing, integration and scale-up of microfluidic systems for chemical and biochemical discovery, synthesis and processing. Chemical kinetics and transport phenomena related to processing of organic and inorganic materials for electronic and optical applications are also topics of interest along with development of simulation approaches for reactive systems, specifically simulation across multiple length and time scales. He is the co-author of more than 550 journal and conference publications as well as several edited volumes and 40 US patents. He is the recipient of several awards, including a National Science Foundation Presidential Young Investigator Award, a Camille and Henry Dreyfus Foundation Teacher-Scholar Grant, a Guggenheim Fellowship, and the Allan P. Colburn, Charles C.M. Stine, R.H. Wilhelm, and W.H. Walker Awards of the American Institute of Chemical Engineers. He received the inaugural IUPAC-ThalesNano Prize in Flow Chemistry in 2012 and AIChE Founders Award for outstanding contributions to the field of Chemical Engineering. Professor Jensen is a member of the US National Academy of Engineering, US National Academy of Sciences and the American Academy of Arts and Science. He is also a Fellow of the American Association for the Advancement of Science (AAAS), and the American Institute of Chemical Engineers, and the Royal Society of Chemistry.

报告简介

Over the two past decades, microreactor technology has matured from simple demonstration examples to applications in pharmaceuticals and fine chemicals. The field has moved to continuous multistep synthesis of active pharmaceutical ingredients (APIs) by incorporating in-line workup techniques. Integration of on-line measurements of reactant flows, reactor temperature, and outlet concentrations with feedback control systems has enabled automated optimization of reaction yields as well as determining kinetic information. The present contribution starts with automated screening and optimization of chemical reaction in microsystems and continues with integration of small-scale reactors and separators in on-demand continuous synthesis of APIs. As an example of process integration for on demand manufacturing, we present a plug-and-play, reconfigurable, refrigerator-sized manufacturing platform for on-demand synthesis of common pharmaceuticals, e.g. ciprofloxacin. This flexible system is capable of complex multi-step synthesis, in-line purification, post-synthesis work-up and formulation. Multistep synthesis occurs at elevated temperatures and pressures to enhance reaction rates, and the resulting residence times are a few minutes, in contrast to the multiple hour-long synthesis typically needed for batch.